{"slug": "o-geog-dist", "title": "Geographical Distribution of Congenital Anomalies in Malta & Gozo 1993-2004 (November 2006)", "pdfUrl": "https://dhir.gov.mt/wp-content/uploads/2024/04/o_geog_dist.pdf", "sourcePage": "https://dhir.gov.mt/en/registries/congenital-anomalies/", "group": "Registry", "topic": "Congenital Anomalies", "tables": [{"caption": "Table 1: Comparison of Region with highest prevalence with the National Prevalence", "header": ["Anomaly group", "Region with highestprevalence/ 10000 livebirths", "", "Nationalprevalence /10000 livebirths", "p-value"], "rows": [["Neural tube defects", "North", "14.23", "11.38", "0.56"], ["Transposition of great vessels", "SouthernHarbour", "7.78", "4.36", "0.15"], ["Tetralogy of fallot", "Gozo &Comino", "7.16", "3.16", "0.25"], ["Ventricular septal defects", "Gozo &Comino", "66.79", "59.53", "0.54"], ["Hypoplastic left heart", "South East", "7.13", "2.28", "0.015*"], ["Coarctation of aorta", "South East", "7.13", "5.12", "0.46"], ["Cleft lip with/without cleft palate", "Gozo &Comino", "14.31", "8,53", "0.22"], ["Cleft palate without cleft lip", "SouthernHarbour", "14.59", "11.76", "0.45"], ["Anorectal atresia and stenosis", "West", "6.61", "3.98", "0.30"], ["Renal defects", "North", "17.79", "12.89", "0.25"], ["Major hypospadias", "SouthernHarbour", "23.34", "16.50", "0.12"], ["Limb reduction defects", "South East", "8.32", "5.31", "0.28"], ["Polydactyly", "North", "20.16", "16.31", "0.07"], ["Diaphragmatic hernia", "South East", "5.94", "4.55", "0.58"], ["Omphalocele", "West", "5.29", "1.71", "0.047*"], ["Gastroschisis", "Gozo &Comino", "2.39", "1.14", "0.48"], ["Down Syndrome", "Gozo&Comino", "23.85", "18,58", "0.45"], ["All chromosomal anomalies", "Gozo &Comino", "35.78", "26.17", "0.24"]]}, {"caption": "Table 2: Southern Harbour by Northern Harbour, Gozo & Comino", "header": ["Southern Harbour", "Northern Harbour", "Gozo & Comino"], "rows": [["Valletta", "Quormi", "Rabat (Gozo)"], ["Birgu", "Birkirkara", "Fontana"], ["Isla", "Gzira", "Ghajnsielem & Comino"], ["Bormla", "Hamrun", "Gharb"], ["Zabbar", "Msida", "Ghasri"], ["Fgura", "Pembroke", "Kercem"], ["Floriana", "Pieta", "Munxar"], ["Kalkara", "San Giljan", "Nadur"], ["Luqa", "San Gwann", "Qala"], ["Marsa", "Santa Venera", "San Lawrenz"], ["Paola", "Sliema", "Sannat"], ["Santa Lucija", "Swieqi", "Xaghra"], ["Tarxien", "Ta'Xbiex", "Xewkija"], ["Xghajra", "", "Zebbug (Gozo)"]]}, {"caption": "Table 2: Southern Harbour by Northern Harbour, Gozo & Comino (cont. 2)", "header": ["South East", "West", "North"], "rows": [["Zejtun", "Mdina", "Gharghur"], ["Birzebbugia", "Zebugg", "Mellieha"], ["Gudja", "Siggiewi", "Mgarr"], ["Ghaxaq", "Attard", "Mosta"], ["Kirkop", "Balzan", "Naxxar"], ["Marsascala", "Dingli", "San Pawl il-Bahar"], ["Marsaxlokk", "Iklin", ""], ["Mqabba", "Lija", ""], ["Qrendi", "Rabat", ""], ["Safi", "Mtarfa", ""], ["Zurrieq", "", ""]]}, {"caption": "Table 4: Region by Livebirths, Cases, Prevalence/10000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "10", "9.73", "4.94", "18.53"], ["Northern Harbour", "13847", "19", "13.72", "8.5", "21.86"], ["South East", "8415", "8", "9.51", "4.42", "19.54"], ["Western", "7566", "7", "9.25", "4.05", "19.97"], ["Northern", "8433", "12", "14.23", "7.71", "25.61"], ["Gozo & Comino", "4192", "4", "9.54", "3.06", "26.21"]]}, {"caption": "Table 5: Region by Livebirths, Cases, Prevalence/10000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "8", "7.78", "3.62", "15.99"], ["Northern Harbour", "13847", "7", "5.06", "2.22", "10.92"], ["South East", "8415", "3", "3.57", "0.92", "11.35"], ["Western", "7566", "3", "3.97", "1.02", "12.63"], ["Northern", "8433", "1", "1.19", "0.06", "7.7"], ["Gozo & Comino", "4192", "1", "2.39", "0.12", "15.48"]]}, {"caption": "Table 6: Region by Livebirths, Cases, Prevalence/10000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "5", "4.86", "1.79", "12.06"], ["Northern Harbour", "13847", "2", "1.44", "0.25", "5.82"], ["South East", "8415", "3", "3.57", "0.92", "11.53"], ["Western", "7566", "3", "3.97", "1.02", "12.63"], ["Northern", "8433", "3", "3.56", "0.92", "11.33"], ["Gozo & Comino", "4192", "3", "7.16", "1.85", "22.78"]]}, {"caption": "Table 7: Distribution of VSD prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "65", "63.22", "49.21", "81.04"], ["Northern Harbour", "13847", "74", "53.44", "42.27", "67.43"], ["South East", "8415", "52", "61.79", "46.64", "81.61"], ["Western", "7566", "40", "52.87", "38.29", "72.67"], ["Northern", "8433", "54", "64.03", "48.6", "84.12"], ["Gozo & Comino", "4192", "28", "66.79", "45.28", "97.77"]]}, {"caption": "Table 8: Distribution of hypoplastic left heart prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "2", "1.95", "0.34", "7.84"], ["Northern Harbour", "13847", "2", "1.44", "0.25", "5.82"], ["South East", "8415", "6", "7.13", "2.90", "16.36"], ["Western", "7566", "1", "1.32", "0.07", "8.58"], ["Northern", "8433", "1", "1.19", "0.06", "7.70"], ["Gozo & Comino", "4192", "0", "0", "0.22", "11.41"]]}, {"caption": "Table 9: Distribution of Coarctation of aorta according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10,000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "5", "4.86", "1.79", "12.06"], ["Northern Harbour", "13847", "8", "5.78", "2.69", "11.87"], ["South East", "8415", "6", "7.13", "2.9", "16.36"], ["Western", "7566", "1", "1.32", "0.07", "8.58"], ["Northern", "8433", "5", "5.93", "2.18", "14.70"], ["Gozo & Comino", "4192", "2", "4.77", "0.83", "19.22"]]}, {"caption": "Table 10: Region by Livebirths, Cases, Prevalence/10,000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10,000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "10", "9.73", "4.94", "18.53"], ["Northern Harbour", "13847", "14", "10.11", "5.75", "17.42"], ["South East", "8415", "5", "5.94", "2.19", "14.73"], ["Western", "7566", "3", "3.97", "1.02", "12.63"], ["Northern", "8433", "7", "8.30", "3.64", "17.92"], ["Gozo & Comino", "4192", "6", "14.31", "5.82", "32.82"]]}, {"caption": "Table 11: Distribution of Cleft palate prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10,000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "15", "14.59", "8.48", "24.66"], ["Northern Harbour", "13847", "17", "12.28", "7.39", "20.10"], ["South East", "8415", "11", "13.07", "6.88", "24.15"], ["Western", "7566", "6", "7.93", "3.22", "18.19"], ["Northern", "8433", "8", "9.49", "4.41", "19.49"], ["Gozo & Comino", "4192", "5", "11.93", "4.39", "29.55"]]}, {"caption": "Table 12: Region by Livebirths, Cases, Prevalence/10,000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10,000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "3", "2.92", "0.75", "9.92"], ["Northern Harbour", "13847", "6", "4.33", "1.76", "9.94"], ["South East", "8415", "3", "3.57", "0.92", "11.35"], ["Western", "7566", "5", "6.61", "2.43", "16.38"], ["Northern", "8433", "2", "2.37", "0.41", "9.56"], ["Gozo & Comino", "4192", "2", "4.77", "0.83", "19.22"]]}, {"caption": "Table 13: Distribution of renal defects prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "10", "9.73", "4.94", "18.53"], ["Northern Harbour", "13847", "19", "13.72", "8.5", "21.86"], ["South East", "8415", "11", "13.07", "6.88", "24.15"], ["Western", "7566", "10", "13.22", "6.72", "25.17"], ["Northern", "8433", "15", "17.79", "10.34", "30.07"], ["Gozo & Comino", "4192", "3", "7.16", "1.85", "22.78"]]}, {"caption": "Table 14: Region by Livebirths, Cases, Prevalence/10000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "24", "23.34", "15.3", "35.29"], ["Northern Harbour", "13847", "18", "13", "7.95", "20.98"], ["South East", "8415", "11", "13.07", "6.88", "24.15"], ["Western", "7566", "14", "18.5", "10.53", "31.86"], ["Northern", "8433", "17", "20.16", "12.14", "32.99"], ["Gozo & Comino", "4192", "3", "7.16", "1.85", "22.78"]]}, {"caption": "Table 15: Region by Livebirths, Cases, Prevalence/10000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "", "", "", ""], ["Northern Harbour", "13847", "7 6", "6.81 4.33", "2.98 1.76", "14.7 9.94"], ["South East", "8415", "7", "8.32", "3.65", "17.96"], ["Western", "7566", "4", "5.29", "1.69", "14.53"], ["Northern", "8433", "1", "1.19", "0.06", "7.7"], ["Gozo & Comino", "4192", "3", "7.16", "1.85", "22.78"]]}, {"caption": "Table 16: Distribution of polydactyly prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "15", "14.59", "8.48", "24.66"], ["Northern Harbour", "13847", "27", "19.5", "13.11", "28.78"], ["South East", "8415", "14", "16.64", "9.47", "28.65"], ["Western", "7566", "11", "14.54", "7.65", "26.86"], ["Northern", "8433", "17", "20.16", "12.14", "32.99"], ["Gozo & Comino", "4192", "2", "4.77", "0.83", "19.22"]]}, {"caption": "Table 17: Region by Livebirths, Cases, Prevalence/10,000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10,000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "10281", "4.86", "4.86", "1.79"], ["Northern Harbour", "13847", "13847", "5.06", "5.06", "2.22"], ["South East", "8415", "8415", "5.94", "5.94", "2.19"], ["Western", "7566", "7566", "5.29", "5.29", "1.69"], ["Northern", "8433", "8433", "3.56", "3.56", "0.92"], ["Gozo & Comino", "4192", "4192", "0", "0", "0.22"]]}, {"caption": "Table 18: Distribution of omphalocele prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "0", "0", "0.09", "4.66"], ["Northern Harbour", "13847", "2", "1.44", "0.25", "5.82"], ["South East", "8415", "1", "1.19", "0.06", "7.71"], ["Western", "7566", "4", "5.29", "1.69", "14.53"], ["Northern", "8433", "2", "2.37", "0.41", "9.56"], ["Gozo & Comino", "4192", "0", "0", "0.22", "11.41"]]}, {"caption": "Table 19: Distribution of Gastroschisis prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "0", "0", "0.09", "4.66"], ["Northern Harbour", "13847", "3", "2.17", "0.56", "6.9"], ["South East", "8415", "1", "1.19", "0.06", "7.71"], ["Western", "7566", "0", "0", "0.12", "6.33"], ["Northern", "8433", "1", "1.19", "0.06", "7.7"], ["Gozo & Comino", "4192", "1", "2.39", "0.12", "15.48"]]}, {"caption": "Table 20: Distribution of Down syndrome prevalence according to Region (1993 \u2013 2004)", "header": ["Region", "Livebirths", "Cases", "Prevalence/10,000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Harbour", "10281", "17", "16.54", "9.95", "27.06"], ["Northern Harbour", "13847", "25", "18.05", "11.94", "27.07"], ["South East", "8415", "15", "17.83", "10.36", "30.13"], ["Western", "7566", "16", "21.15", "12.52", "35.14"], ["Northern", "8433", "15", "17.79", "10.34", "30.07"], ["Gozo & Comino", "4192", "10", "23.85", "12.13", "45.4"]]}, {"caption": "Table 21: Region by Livebirths, Cases, Prevalence/10,000 Livebirths", "header": ["Region", "Livebirths", "Cases", "Prevalence/10,000 Livebirths", "Lower 95% CI", "Upper 95% CI"], "rows": [["Southern Ha rbour", "10281", "23", "22.37", "14.52", "34.13"], ["Northern Harbour", "13847", "36", "26", "18.48", "36.39"], ["South East", "8415", "21", "24.96", "15.86", "38.84"], ["Western", "7566", "21", "27.76", "17.64", "43.19"], ["Northern", "8433", "22", "26.09", "16.76", "40.18"], ["Gozo & Comino", "4192", "15", "35.78", "20.8", "60.44"]]}]}